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If problematic, reduce dose

This approach has been used recently to study the trafficking profiles of GLP-1R mono-agonists and dual GLP-1R/GIPR co-agonists (Fletcher et al ., 2018

Front Physiol 12:606931 Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay B-H, Sugii S, Sun L (2019) Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy