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DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid Chemical Name: 4-((4-((((1R

DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid Chemical Name: 4-((4-((((1R

Name: DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid Chemical Name: 4-((4-((((1R
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SKU: 97837134297
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DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid Chemical Name: 4-((4-((((1RDASA 58 (ML203), CAS No. 1203494 49 8, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. DASA 58 inhibits LPS induced Hif 1 and IL 1, as well as the expression of a range of other Hif 1 dependent

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Chemical Name: 4-((4-((((1R

2007 May 1

It is highly selective over related enzymes such as MAO-A/B

which are osteogenic factors that regulate the maturation of osteogenic progenitor cells into more differentiated osteoblast cells

(2012) Nature 485(7396):123-7

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