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It has been shown that in patients with TBI, intracerebral axonal deformities persist several years after injury and that DAI may induce long-term progressive neurodegenerative processes ( Posttraumatic Epilepsy (PTE) Posttraumatic Epilepsy is a common symptom after TBI and occurs in approximately 30% of patients with severe TBI (Verellen and Cavazos, 2010)

For instance, in the myocardium of exhaustive-exercised rats, TMZ produced specific cardioprotective outcomes by increasing GSH and GPX activity to clear oxidative stress

Nat Commun (2014) 5:3611.10.1038/ncomms4611 171 MacFabeDF

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