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Paxlovid (nirmatrelvir/ritonavir) Disease area(s): Infectious diseases (antivirals) Manufacturer(s): Pfizer 2024 Sales (USD): $5.72 billion Why it sold so well: In 2024, Pfizers COVID-19 antiviral treatment, Paxlovid, generated $5.72 billion in global revenue, making it the companys third-highest-selling product for the year