The term pathogenesis should be used instead of pathogenies. Abbreviations ADCs: Antibody drug conjugates mAb: Monoclonal antibody RA: Rheumatoid arthritis DMARDs: Disease modifying anti-rheumatic drugs MHC: Major histocompatibility complex HLA: Human leukocyte antigen TNF: Tumour necrosis factor IL: Interleukin RF: Rheumatoid factor ACPA: Anti-citrullinated protein antibodies MMPs: Matrix metalloproteinases FLS: Fibroblast like synoviocytes Th cells: T-helper cells CD: Cluster of differentiation TCR: T cell receptor APCs: Antigen presenting cells RANK: Receptor activator of nuclear factor B Cs: Corticosteroids NDSAIDs: Non-steroidal anti-rheumatic drugs ACR: American College of Rheumatology BMI: Body mass index PUFAs: Polyunsaturated fats bDMARDs: Biological disease modifying anti-rheumatic drugs EULAR: European Alliance of Associations for Rheumatology COX: Cyclooxygenase HPA: Hypothalamic-pituitary-adrenal MTX: Methotrexate SSZ: Sulfadiazine HCQ: Hydroxychloroquine JAKi: Janus-kinase inhibitors HZ: Herpes zoster IFX: Infliximab FDA: Food and Drug administration Ig: Immunoglobulins CDC: Complement dependent cytotoxicity ADCC: Antibody-dependent cell mediated cytotoxicity IFN: Interferon GRM: Glucocorticoid receptor modulator ADM: Adalimumab MMAE: Monomethyl auristatin E CAIA: Collagen antibody induced arthritis References Almutairi K, Nossent J, Preen D, Keen H, Inderjeeth C
But these defensive actions of endothelial cells can, if overexuberant, aggravate disease
Use the opposite side of your body from where you see any residual discoloration, small bruising, or slight tenderness
Anything less, and you risk increasing oxidative stress and decreasing natural glutathione levels
How will we measure progress beyond the scale (waist, labs, strength, hunger control)
