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While tirzepatide does not undergo significant renal clearance, limited safety data exist in severe kidney disease

The processing and analysis of 1 H-MRS data were conducted using the GABA Analysis Toolkit (Gannet, version 3.0) 59 implemented in MATLAB R2017b (MathWorks Inc., Natick, USA)

For example, pathogenic variants in the SDHB and SDHC proteins have been associated with paragangliomas and pheochromocytomas

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High levels of NNMT expression have also been reported at both mRNA and protein levels in Merkel cell carcinoma [230] and ovarian cancer [231] as a poor prognostic feature and an advantage for cancer progression