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JNK-IN-8 - CAS# 1410880-22-6 Catalog No.:M6416-10 PubMed Central PMCID: PMC4752338

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JNK-IN-8 - CAS# 1410880-22-6 Catalog No.:M6416-10 PubMed Central PMCID: PMC4752338JNK IN 8, also known as JNK Inhibitor XVI, CAS No. 1410880 22 6, is a selective JNK inhibitor that inhibits phosphorylation of c Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue. Extensive biochemical, cellular, and pathway based profiling establish the selectivity of JNK IN 8 for JNK and suggests that the compound will be broadly useful as a

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PubMed Central PMCID: PMC4752338

indicating that cycling populations of normal cells induce Chk1 pS345 following exposure to MK-8776 S-isomer as part of a futile cycle

CAS Number: 501919-59-1

Katayama R

Formula: C27H32N8O2

JNK-IN-8 - CAS# 1410880-22-6 Catalog No.:M6416-10 PubMed Central PMCID: PMC4752338JNK IN 8, also known as JNK Inhibitor XVI, CAS No. 1410880 22 6, is a selective JNK inhibitor that inhibits phosphorylation of c Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue. Extensive biochemical, cellular, and pathway based profiling establish the selectivity of JNK IN 8 for JNK and suggests that the compound will be broadly useful as a

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