WWL113 - Ces3 and Ces1f Inhibitor. CAS# 947669-86-5 075 1401966-63-9 (meso)

1401966-63-9 (meso)

GNF-2 interfered with actin cytoskeletal organization and subsequently blocked the bone-resorbing activity of mature osteoclasts

InChiKey: AKIIPHDGVCFVCC-UHFFFAOYSA-N

It inhibits Wee1 in H3K36me3-deficient cells results in RRM2 reduction

exhibits more selective for inhibiting BTK and has virtually no inhibition of platelet activity

WWL113 - Ces3 and Ces1f Inhibitor. CAS# 947669-86-5 075 1401966-63-9 (meso)WWL113, CAS No. 947669 86 5, is a novel potent and selective inhibitor of Ces3 and Ces1f with IC50 ~0. 1 M in cellular assays. WWL113 was discovered by a high throughput screen. Carboxylesterase 3 (Ces3, also known as Ces1d) plays a key role in lipid metabolism (e. g., hydrolyzing long chain fatty acid esters and thioesters) and promotes lipid storage in adipocytes. Ces3 activity is markedly elevated during adipocyte differentiation. Treatment of two