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Preclinical studies in obese animal models further indicate that AOD 9604 enhances lipolytic activity within adipose tissue, with preferential effects observed in metabolically dysregulated fat cells [2]

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This poor oral bioavailability explains why clinical trials used subcutaneous injection

Factors like stress, poor gut health, or certain medications can reduce absorption even further

The proportion of participants achieving 20% or greater weight loss was 36% at the 10mg dose and 40% at the 15mg dose, results approaching what was previously achievable only with bariatric surgery