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however, it experiences considerable first-pass metabolism, culminating in a brief plasma half-life of approximately 13 h, contingent upon the species and formulation utilized ( 3 Mechanistic basis of luteolin's neuroprotective activity Luteolin exerts neuroprotection through pleiotropic actions on inflammation, oxidative stress, synaptic function, cell death pathways and proteostasis ( 3.1 Anti-inflammatory mechanisms Neuroinflammation, orchestrated primarily through the activation of microglia and astrocytes, acts as a trigger for the progression of neurodegenerative diseases

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August 22, 2023

PubMed PMID: 16809911 Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake