MAK-683 - CAS# 1951408-58-4 size:10mg solid Prinaberel (2mg/mouse

Prinaberel (2mg/mouse

Te Poele RH

3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H

DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis

Chemical Name: N-(1

MAK-683 - CAS# 1951408-58-4 size:10mg solid Prinaberel (2mg/mouseMAK 683, CAS No. 1951408 58 4, is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3 binding pocket and prevents the interaction of EED