TAS0728 Size:10 mg solid [Epub ahead of print] PubMed

[Epub ahead of print] PubMed PMID: 22495798

is a novel PDK1 (phosphoinositide-dependent protein kinase 1) activator (Kd = 10

a potent and selective inhibitor of polo-like kinase 1

CAS Number: 327036-89-5

Stensbøl TB

TAS0728 Size:10 mg solid [Epub ahead of print] PubMedTAS0728 (TPC 107) is a potent, selective, orally active, irreversible and covalent binding inhibitor of HER2 (human epidermal growth factor receptor 2) with IC50 of 13 nM. TAS0728 inihibits BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2 with IC50 of 4. 9 nM, 8. 5 nM, 31 nM, 65 nM, 33 nM, 25 nM, 86 nM and 36 nM, respectively. TAS0728 shows antitumor activity. Product information CAS Number: 2088323 16 2 Molecular Weight: 504. 58 Formula: