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All experiments were conducted as in the previous formalin model study

In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]

Since GHR expression in the kidney is unaltered in T1DM, elevated circulating GH-concentrations can impact on the kidney

30 GaoS.ZhouL.LuJ.FangY.WuH.XuW.et al (2022)

In the SURMOUNT-1 extension study, participants who stopped tirzepatide regained approximately two-thirds of their lost weight within one year