OTS514 - TOPK inhibitor. CAS# 1338540-63-8 Catalog No.:M6618-10 SW044248 shows no effect on

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OTS514 - TOPK inhibitor. CAS# 1338540-63-8 Catalog No.:M6618-10 SW044248 shows no effect onOTS514 TOPK inhibitor, CAS No. 1338540 63 8, is a potent TOPK (T LAK cell originated protein kinase) inhibitor. OTS514 exhibits growth suppressive effect on small cell lung cancer. TS514 effectively suppressed growth of SCLC cell lines (IC50 ; 0. 4 ~ 42. 6 nM) and led to their apoptotic cell death. Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity, which was involved in stemness of CSC. Furthermore, OTS514 treatment reduced

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