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AngII is the major effector of RAAS, acting on AngII receptor type 1 (AT1), causing contraction of the smooth muscle of the arteriole and stimulating the adrenocortical spherical band to secrete aldosterone

Yes, Jardiance has been shown to help adult patients with type 2 diabetes lose weight, but it is not approved as a weight loss medicine

Reduce neuroinflammation and oxidative stress, potentially lowering the risk of cognitive decline

Liraglutide (Victoza) and dulaglutide (Trulicity) show the same pattern

Without a companion program, its possible to end up with sarcopenic obesity and a higher body fat composition than before starting the meds up to 40% of weight loss can be muscle