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Our results suggested that insulin gene therapy combined with anti-inflammatory/insulinotropic/regenerative gene delivery was more effective than their individual applications

327,328 Also, -cell encapsulation techniques provide a physical barrier that shields transplanted -cells from immune attack while allowing the exchange of nutrients and insulin

Effective immune functions of micronutrients against SARS-CoV-2

These benefits are particularly evident in conditions like nonalcoholic steatohepatitis (NASH), where GLP-1RAs alleviate inflammation and boost insulin sensitivity, leading to improved hepatic glucose management and reduced steatosis ( This review examines the impact of GLP-1RAs on liver health and their potential applications in the treatment of liver diseases

In addition, all subjects attended four-weekly telephone follow-up visits with a healthcare assistant which aimed to reduce discontinuation and offer additional time to stabilise before subsequent dose escalation