MDV-3100 - CAS# 915087-33-1 60135 17(4):316-22

17(4):316-22

Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases

unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase/endoRNase (RNase) IRE1α

Targeting the multiple myeloma hypoxic niche with TH-302

is an allosteric inhibitor of Bcr-abl tyrosine kinase activity (IC50 = 267 nM)

MDV-3100 - CAS# 915087-33-1 60135 17(4):316-22Enzalutamide, also known as MDV3100, CAS No. 915087 33 1, is an orally bioavailable, organic, non steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, selective androgen receptor modulator MDV3100 inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation