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For the L-carnitine challenge study ( n = 47), male and female homozygous APOE2-, APOE3-, and APOE4-TR mice were euthanized at 53-weeks (Supplementary Table S3)

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Animal studies help explore biological questions in model systems

AI-driven hypoxia imaging using advanced radiomic and deep-learning models applied to MRI, PET, or multiparametric CT scan can non-invasively quantify hypoxic burden, monitor temporal changes during therapy, and guide adaptive treatment strategies (321323)

NAD+ supports mitochondrial function and DNA repair across all cell types, including neurons