AZD-5438 Size:Solid 2 mg Potent and Selective Triazole-Based Inhibitors

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

selective and bioavailable CK2 (Casein Kinase 2) Inhibitor with IC50 of 1 nM

ZINC4758640

the major inhibitory neurotransmitter in the central nervous system by blocking the GABA transporter and hence is classified as a GABA reuptake inhibitor

which is an angiotensin converting enzyme (ACE) inhibitor

AZD-5438 Size:Solid 2 mg Potent and Selective Triazole-Based InhibitorsAZD5438 is a potent inhibitor of cyclin dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC(50) range, 0. 2 1. 7 micromol L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH terminal domain and blocking cell cycling at G(2) M, S, and G(1) phases.