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Infine, diversi studi, sia in vitro che in vivo , hanno dimostrato che questi farmaci esercitano un effetto protettivo sulle cellule beta del pancreas , promuovendone la proliferazione e la nuova sintesi, a partire da cellule progenitrici

However, both can affect gastrointestinal function, so the combination may increase digestive side effects initially

For patients with significant portal hypertension or ascites, deltoid or lateral thigh injection sites avoid the potentially altered abdominal vascular dynamics

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