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A recent study ( The Emerging Role of SGLT2-i in Cardio-Nephroprotection SGLT2 is a low-affinity high-capacity co-transporter distributed mainly along the early segments of the proximal renal tubule

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This cytokine induces phosphorylation of downstream SMAD2/3 and, through p53-dependent mechanisms, upregulates PAI-1- culminating in fibrotic tissue remodeling [60]

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