IκB-alpha(Phospho Tyr305) Polyclonal Antibody, 50ul Isothermal Amplification PubMed: 23352644

PubMed: 23352644

These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha"

Mutations in this gene cause nephronophthisis (NPHP)| an autosomal recessive kidney disease characterized by tubular basement membrane disruption| interstitial lymphohistiocytic cell infiltration| and development of cysts at the corticomedullary border of the kidneys

Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency

Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold

IκB-alpha(Phospho Tyr305) Polyclonal Antibody, 50ul Isothermal Amplification PubMed: 23352644This gene encodes a member of the NF kappa B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF kappa B REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1 mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T cell