ALS2 Polyclonal Antibody, 50ul Variant Libraries Several pseudogenes of this gene

Several pseudogenes of this gene have been identified

which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus

DNA damage response

subunit:Interacts with SH3GL1/endophilin-2

Isoform 1 is the lowest abundant in the blood

ALS2 Polyclonal Antibody, 50ul Variant Libraries Several pseudogenes of this geneThe protein encoded by this gene contains an ATS1 RCC1 like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics.