Chk1(Phospho Ser286) Polyclonal Antibody, 20ul sgRNA Library Construction Alternative splicing of SRPK1 results

Alternative splicing of SRPK1 results in multiple transcript variants

In some types of Ewing tumors

The protein lacks critical active site residues and thus is suggested to be proteolytically inactive

The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein

The alpha subunit includes the skeletal muscle and hepatic isoforms

Chk1(Phospho Ser286) Polyclonal Antibody, 20ul sgRNA Library Construction Alternative splicing of SRPK1 resultsThe protein encoded by this gene belongs to the Ser Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells