SPDEF Polyclonal Antibody, 100ul Recombinant Ab Production The encoded preproprotein is proteolytically

The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide| and is found in either a latent form composed of a mature peptide homodimer| a LAP homodimer| and a latent TGF-beta binding protein| or in an active form consisting solely of the mature peptide homodimer

GO annotations related to this gene include signal transducer activity and G-protein beta-subunit binding

Multiple alternately spliced transcript variants which encode different protein isoforms have been described

copper- and zinc- binding domains at the N-terminus

Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease

SPDEF Polyclonal Antibody, 100ul Recombinant Ab Production The encoded preproprotein is proteolyticallyThe protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen independent transactivator of prostate specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor association than other cancer associated