Granulins Rabbit Polyclonal Antibody, 20ul Live Cell Imaging tissue specificity:Highly expressed in surface

tissue specificity:Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia

Studies in other mammals suggest this protein plays a role in cell adhesion

The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity

The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone

It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro

Granulins Rabbit Polyclonal Antibody, 20ul Live Cell Imaging tissue specificity:Highly expressed in surfacedisease: Defects in GRN are the cause of ubiquitin positive frontotemporal dementia (UP FTD)