MARCKS Polyclonal Antibody, 50ul[BT-AP05218] Syringe Filter Most isoforms share a common

Most isoforms share a common C-terminal domain

Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation

is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types

or nemaline

The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor

MARCKS Polyclonal Antibody, 50ul[BT-AP05218] Syringe Filter Most isoforms share a commonThe protein encoded by MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.