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The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction

The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell

The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly

Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain

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