Raf-1 Polyclonal Antibody, 100ul[BT-AP07628] Plasmid Preparation Caspases exist as inactive proenzymes

Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits

Two related pseudogenes have been identified on chromosome X

also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini

This family member is localized to 11q12

Two similar genes are located nearby on chromosome 7q22 and a pseudogene is found on chromosome 7p13

Raf-1 Polyclonal Antibody, 100ul[BT-AP07628] Plasmid Preparation Caspases exist as inactive proenzymesRAF1 (Raf 1 proto oncogene, serine threonine kinase) is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine