NF-1 Polyclonal Antibody, 100ul Mammalian Expression multiple potential phosphorylation sites

multiple potential phosphorylation sites

The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the Catalytic activity is acquired

Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia

and the formation of metastases (PubMed: 16636290)

and Paget disease of bone

NF-1 Polyclonal Antibody, 100ul Mammalian Expression multiple potential phosphorylation sitesNFIA encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene.