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the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes

p66Shc is not involved in Ras activation

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Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism

SWAP Polyclonal Antibody, 20ul Roller Bottles • Speed can be setSFSWAP encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified.