EpoR(Phospho Tyr426) Polyclonal Antibody, 100ul Cell Culture Flasks Alternate splicing of EPN2 results

Alternate splicing of EPN2 results in multiple transcript variants encoding different isoforms

The encoded protein may play a role in regulating p53-mediated apoptosis

NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65| RELB| NFKB1/p105| NFKB1/p50| REL and NFKB2/p52

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs

whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle

EpoR(Phospho Tyr426) Polyclonal Antibody, 100ul Cell Culture Flasks Alternate splicing of EPN2 resultsThis gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras MAP kinase, phosphatidylinositol 3 kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce