p27 Monoclonal Antibody, 100ul Erlenmeyer Flasks The gene product is a

The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits

It is a secreted protein and may function as a homodimer

The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends

Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis

Caspases exist as inactive proenzymes composed of a prodomain| a large protease subunit| and a small protease subunit

p27 Monoclonal Antibody, 100ul Erlenmeyer Flasks The gene product is aThis gene encodes a cyclin dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A p21. The encoded protein binds to and prevents the activation of cyclin E CDK2 or cyclin D CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from