Grap Polyclonal Antibody, 100ul Virus Packaging whose activity is required for

whose activity is required for cell cycle G1/S transition

The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product

Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates

The protein is activated by heparin

and exons 6 and 7 encode the cytoplasmic tail

Grap Polyclonal Antibody, 100ul Virus Packaging whose activity is required forGRAP encodes a member of the GRB2 Sem5 Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through