AGRIN Polyclonal Antibody, 100ul Miscellaneous Multiple alternatively spliced transcript variants

Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene

The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome

where it is induced by ER stress caused by malfolded proteins

Isoform 4 is also expressed in Leydig cells

and the membrane-spanning component

AGRIN Polyclonal Antibody, 100ul Miscellaneous Multiple alternatively spliced transcript variantsThis gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ) as identified in mouse knock out studies. The encoded protein contains several laminin G Kazal type serine protease inhibitor and epidermal growth factor domains. Additional post translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb girdle muscles