Shc(Phospho Tyr427) Polyclonal Antibody, 50ul Cell Culture Flasks a cytoplasmic signaling molecule that

a cytoplasmic signaling molecule that mediates effects of insulin

These receptors are composed of an N-terminal glycosylated ligand-binding domain

Modulates signaling via SHC1 by competing for a common binding site on NTRK1

5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway

consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55

Shc(Phospho Tyr427) Polyclonal Antibody, 50ul Cell Culture Flasks a cytoplasmic signaling molecule thatThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.