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Description

2021;118:e2020803118

NCT-503 reduces glucose-derived serine production and the incorporation of one-carbon units into nucleotides without decreasing PHGDH protein expression

A diabetic patient is given a Sub-Q hormone injection

Semaglutide (HXEGTFTSDVSSYLEGQAAK(C18diacid-E-OEG-OEG)EFIAWLVRGRG), another long acting GL1-RA, has two amino acid substitutions compared to human GLP-1 (2-aminoisobutyric acid (Aib) 8, arginine (Arg) 34) and is derivatized at lysine 26 [84]