PXR Polyclonal Antibody, 100ul General Lab Use MAPKAPK3 encodes a member of

MAPKAPK3 encodes a member of the Ser/Thr protein kinase family (mitogen-activated protein kinase-activated protein kinase 3)

Alternatively-spliced transcript variants have been observed

and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins

the protein associates with spindle microtubules near the centrosomes

implying different ligand specificity

PXR Polyclonal Antibody, 100ul General Lab Use MAPKAPK3 encodes a member ofThis gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand binding domain and a DNA binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9 cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including