Phospho-Btk (Y223) Polyclonal Antibody, 100ul Organelle Studies WWOX (WW domain containing oxidoreductase)

WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family

The protein encoded by this gene is one of three related synaptic vesicle proteins

Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination

This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis

maps to chromosome 6p21

Phospho-Btk (Y223) Polyclonal Antibody, 100ul Organelle Studies WWOX (WW domain containing oxidoreductase)Bruton tyrosine kinase encoded by BTK plays a crucial role in B cell development. Mutations in BTK cause X linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.