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LRRK2 Polyclonal Antibody, 50ul Miscellaneous Binds to the signal sequence

SKU: 6921439331

4.1
DKK162.00 DKK199.00

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LRRK2 Polyclonal Antibody, 50ul Miscellaneous Binds to the signal sequenceThis gene is a member of the leucine rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine rich repeat (LRR) domain, a kinase domain, a DFG like motif, a RAS domain, a GTPase domain, a MLK like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease 8.

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Description

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)

It forms a unique glycan

and acts as a tumor suppressor in hepatoma cells

In the developing cortex| cortical neurons must migrate over long distances to reach the site of their final differentiation

This receptor associates with guanine-nucleotide-binding (G) proteins

LRRK2 Polyclonal Antibody, 50ul Miscellaneous Binds to the signal sequenceThis gene is a member of the leucine rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine rich repeat (LRR) domain, a kinase domain, a DFG like motif, a RAS domain, a GTPase domain, a MLK like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease 8.

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