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3 Palliative Research Center (PaRC), University of Pittsburgh, Pittsburgh, PA

Effect of the Pineal Gland Peptide Preparation Epithalamin on the Lifespan and Spontaneous Tumour Incidence in Female SHR Mice Mechanisms of Ageing and Development Epithalamin treatment begun in old age increased mean lifespan of female SHR mice by 12.3%, reduced spontaneous tumour incidence, and inhibited tumour growth rate extending maximum lifespan

Reported Side Effects by Dose Level Most gastrointestinal side effects were mild to moderate and occurred primarily during dose escalation