Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette The protein encoded by this

The protein encoded by this gene is a member of the shugoshin family of proteins

This gene is widely expressed in many tissues with the greatest abundance in brain and testis

Required for proper attachment of the midbody to the cell membrane during cytokinesis

Alternative splicing results in multiple transcript variants encoding distinct isoforms

Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly

Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette The protein encoded by thisCell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical