CI072 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Amplification and studies in mice show

and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease

It is thought that this family member is functional in brain due to its high expression levels there

IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion

The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C)

Low BMD is a risk factor for osteoporotic fracture

CI072 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Amplification and studies in mice showThe protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2 22 copies to 700 1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia)