JTB Polyclonal Antibody, 100ul Cell Function Analysis Guanine nucleotide exchange factor (GEF)

Guanine nucleotide exchange factor (GEF) for RAP1A

This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons

The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase

and play important roles in cell growth

and the mature nuclear form is rapidly catabolized

JTB Polyclonal Antibody, 100ul Cell Function Analysis Guanine nucleotide exchange factor (GEF)Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits