Rat Neurogenic Locus Notch Homolog Protein 1, NOTCH1 ELISA Kit, 96T Bio-Reaction Tube especially for normal development of

especially for normal development of the craniofacial skeleton and for normal development of the palate

The protein positively regulates the downstream effector ribosomal protein S6 kinase| and negatively regulates the mTOR kinase

subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo

The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix

and are functionally distinct

Rat Neurogenic Locus Notch Homolog Protein 1, NOTCH1 ELISA Kit, 96T Bio-Reaction Tube especially for normal development ofFunctions as a receptor for membrane bound ligands Jagged 1 (JAG1), Jagged 2 (JAG2) and Delta 1 (DLL1) to regulate cell fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By