APBB3 Rabbit Polyclonal Antibody, 100ul Funnels Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding multiple isoforms have been observed for ITCH

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with deletion of the Golgi and endoplasmic reticulum signals resulting in abnormal subcellular localization

APBB3 Rabbit Polyclonal Antibody, 100ul Funnels Alternatively spliced transcript variants encodingThe protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta amyloid precursor protein (APP) as well as to other APP like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.