Rb Polyclonal Antibody, 50ul[BT-AP07685] Peptide Library this protein lacks the platelet-binding
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Rb Polyclonal Antibody, 50ul[BT-AP07685] Peptide Library this protein lacks the platelet-bindingRB transcriptional corepressor 1 encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
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