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Rb Polyclonal Antibody, 50ul[BT-AP07685] Peptide Library this protein lacks the platelet-binding

SKU: 54188584000

4.1
USD185.00 USD218.00

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Rb Polyclonal Antibody, 50ul[BT-AP07685] Peptide Library this protein lacks the platelet-bindingRB transcriptional corepressor 1 encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

this protein lacks the platelet-binding site

This gene is one of the contiguous genes at 7q11

This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P

Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization| inositol triphosphate production and secretion of IL6 and CSF1

This gene encodes a receptor for ephrin-B family members

Rb Polyclonal Antibody, 50ul[BT-AP07685] Peptide Library this protein lacks the platelet-bindingRB transcriptional corepressor 1 encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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