TELT Polyclonal Antibody, 100ul Deep Well Plates Knockout studies in mice suggest

Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macro

This protein is also subject to carboxyl-terminal processing

4-dihydroxyphenylalanine (DOPA) to dopamine

but not the GoLoco 2 domain

Mutations in this gene contribute to mitochondrial complex 1 deficiency

TELT Polyclonal Antibody, 100ul Deep Well Plates Knockout studies in mice suggestSarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1 Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly.