GP112 Polyclonal Antibody, 20ul RNA Tools Mutations in this gene are

Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers

Similarity to the RAS suppressor protein| as well as expression down-regulation observed in tumor cells| suggests that it may function as a tumor suppressor

Three alternatively spliced transcript variants have been described for HNRNPDL

stimulating translocation to the nucleus where it forms homo- or heterooligomers with other members of the microphthalmia transcription factor (MiTF) subfamily and resulting in up-regulation of autophagosomes and lysosomes

encode distinct proteins (PMID: 9207021)

GP112 Polyclonal Antibody, 20ul RNA Tools Mutations in this gene areThis gene encodes a G protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7 transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine