M3K14 Polyclonal Antibody, 20ul Endonucleases & Exonucleases although the functional consequences of

although the functional consequences of these have not yet been established

Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains

It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member

Three transcripts

Not expressed in spleen

M3K14 Polyclonal Antibody, 20ul Endonucleases & Exonucleases although the functional consequences ofThis gene encodes mitogen activated protein kinase kinase kinase 14, which is a serine threonine protein kinase. This kinase binds to TRAF2 and stimulates NF kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF kappaB inducing signalling cascade common to receptors of the tumour necrosis nerve growth factor (TNF NGF) family and to the interleukin 1 type I receptor.